Large-scale structure and the redshift-distance relation

In efforts to demonstrate the linear Hubble law v = Hr from galaxy observations, the underlying simplicity is often obscured by complexities arising from magnitude-limited data. In this paper we point out a simple but previously unremarked fact: that the shapes and orientations of structures in redshift space contain in themselves independent information about the cosmological redshift-distance relation. The orientations of voids in the CfA slice support the Hubble law, giving a redshift-distance power index p = 0.83 +/- 0.36 (void data from Slezak, de Lapparent, & Bijoui 1993) or p = 0.99 +/- 0.38 (void data from Malik & Subramanian 1997).Comment: 11 pages (AASTeX), 4 figures, to appear in the Astrophysical Journal Letter

The Anti-Coincidence Detector for the GLAST Large Area Telescope

This paper describes the design, fabrication and testing of the Anti-Coincidence Detector (ACD) for the Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT). The ACD is LAT first-level defense against the charged cosmic ray background that outnumbers the gamma rays by 3-5 orders of magnitude. The ACD covers the top and 4 sides of the LAT tracking detector, requiring a total active area of ~8.3 square meters. The ACD detector utilizes plastic scintillator tiles with wave-length shifting fiber readout. In order to suppress self-veto by shower particles at high gamma-ray energies, the ACD is segmented into 89 tiles of different sizes. The overall ACD efficiency for detection of singly charged relativistic particles entering the tracking detector from the top or sides of the LAT exceeds the required 0.9997.Comment: 33 pages, 19 figure

Infinite dimensional Lie algebras in 4D conformal quantum field theory

The concept of global conformal invariance (GCI) opens the way of applying algebraic techniques, developed in the context of 2-dimensional chiral conformal field theory, to a higher (even) dimensional space-time. In particular, a system of GCI scalar fields of conformal dimension two gives rise to a Lie algebra of harmonic bilocal fields, V_m(x,y), where the m span a finite dimensional real matrix algebra M closed under transposition. The associative algebra M is irreducible iff its commutant M' coincides with one of the three real division rings. The Lie algebra of (the modes of) the bilocal fields is in each case an infinite dimensional Lie algebra: a central extension of sp(infty,R) corresponding to the field R of reals, of u(infty,infty) associated to the field C of complex numbers, and of so*(4 infty) related to the algebra H of quaternions. They give rise to quantum field theory models with superselection sectors governed by the (global) gauge groups O(N), U(N), and U(N,H)=Sp(2N), respectively.Comment: 16 pages, with minor improvements as to appear in J. Phys.

Heat flux operator, current conservation and the formal Fourier's law

By revisiting previous definitions of the heat current operator, we show that one can define a heat current operator that satisfies the continuity equation for a general Hamiltonian in one dimension. This expression is useful for studying electronic, phononic and photonic energy flow in linear systems and in hybrid structures. The definition allows us to deduce the necessary conditions that result in current conservation for general-statistics systems. The discrete form of the Fourier's Law of heat conduction naturally emerges in the present definition

Radio frequency component and method of making same

An electrical component and a method of constructing it are disclosed. The component includes a hollow tubular structure. The structure includes a series of axially spaced apart rings and at least one outer perimeter housing member. The housing member interconnects the rings for defining an internal configuration of the hollow tubular structure for electrical purposes. The rings and the housing member each include inter-engageable elements for helping secure mechanically the rings and housing member together to facilitate final assembly of the electrical component

Type I D-branes in an H-flux and twisted KO-theory

Witten has argued that charges of Type I D-branes in the presence of an H-flux, take values in twisted KO-theory. We begin with the study of real bundle gerbes and their holonomy. We then introduce the notion of real bundle gerbe KO-theory which we establish is a geometric realization of twisted KO-theory. We examine the relation with twisted K-theory, the Chern character and provide some examples. We conclude with some open problems.Comment: 23 pages, Latex2e, 2 new references adde

Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial.

More efficacious treatment regimens are needed for tuberculosis, however, drug development is impeded by a lack of reliable biomarkers of disease severity and of treatment effect. We conducted a directed screen of host biomarkers in participants enrolled in a tuberculosis clinical trial to address this need. Serum samples from 319 protocol-correct, culture-confirmed pulmonary tuberculosis patients treated under direct observation as part of an international, phase 2 trial were screened for 70 markers of infection, inflammation, and metabolism. Biomarker assays were specifically developed for this study and quantified using a novel, multiplexed electrochemiluminescence assay. We evaluated the association of biomarkers with baseline characteristics, as well as with detailed microbiologic data, using Bonferroni-adjusted, linear regression models. Across numerous analyses, seven proteins, SAA1, PCT, IL-1β, IL-6, CRP, PTX-3 and MMP-8, showed recurring strong associations with markers of baseline disease severity, smear grade and cavitation; were strongly modulated by tuberculosis treatment; and had responses that were greater for patients who culture-converted at 8weeks. With treatment, all proteins decreased, except for osteocalcin, MCP-1 and MCP-4, which significantly increased. Several previously reported putative tuberculosis-associated biomarkers (HOMX1, neopterin, and cathelicidin) were not significantly associated with treatment response. In conclusion, across a geographically diverse and large population of tuberculosis patients enrolled in a clinical trial, several previously reported putative biomarkers were not significantly associated with treatment response, however, seven proteins had recurring strong associations with baseline radiographic and microbiologic measures of disease severity, as well as with early treatment response, deserving additional study

NS5-Branes, T-Duality and Worldsheet Instantons

The equivalence of NS5-branes and ALF spaces under T-duality is well known. However, a naive application of T-duality transforms the ALF space into a smeared NS5-brane, de-localized on the dual, transverse, circle. In this paper we re-examine this duality, starting from a two-dimensional N=(4,4) gauged linear sigma model describing Taub-NUT space. After dualizing the circle fiber, we find that the smeared NS5-brane target space metric receives corrections from multi-worldsheet instantons. These instantons are identified as Nielsen-Olesen vortices. We show that their effect is to break the isometry of the target space, localizing the NS5-brane at a point. The contribution from the k-instanton sector is shown to be proportional to the weighted integral of the Euler form over the k-vortex moduli space. The duality also predicts the, previously unknown, asymptotic exponential decay coefficient of the BPS vortex solution.Comment: 26 pages. v2: Fourier modes of multi-vortex fermion zero mode corrected. Reference added. v3: typo correcte

Resumption of elective orthopaedic surgery in the us epicenter of covid-19

© 2020 Krauss et al. On March 1, 2020, New York State confirmed its first case of COVID-19. This state has had the largest initial mortality in the United States with more than 479,000 confirmed cases and over 25,000 deaths as of October 10, 2020. All elective surgeries in New York State were suspended on March 23, 2020, due to the national state of emergency. Syosset Hospital is a 75-bed community hospital dedicated primarily to elective surgery. During the COVID-19 surge, the hospital was converted to provide needed beds for the treatment of COVID-19 illness. In anticipation of the resumption of urgent elective procedures, this hospital became one of the two designated sites within the Northwell Health system to be “non-COVID.” Once the hospital was emptied of all inpatients, a complete and thorough cleaning and disinfection was performed on the entire building. All equipment was thoroughly decontaminated following Centers for Disease Control and Prevention (CDC) guidelines. In anticipation of the resumption of elective surgery, each surgeon evaluated their cancelled case list to determine patient priority, based on a scale of 1 (elective, non-urgent), 2 (semi-urgent), 3 (urgent), to 4 (highly urgent). Site-specific disaster credentialing was expedited so that emergent surgeries could be performed by surgeons located at other Northwell sites. To ensure a structured and informative onboarding process, each visiting surgeon received a “welcome” email which requested pertinent information to facilitate the surgical process. Presurgical, surgical, and postoperative protocols were revised based on federal and local guidance and regulations. Resumption of elective surgery post COVID-19 placed the hospital into uncharted territory

Representations and KK-theory of Discrete Groups

Let $\Gamma$ be a discrete group of finite virtual cohomological dimension with certain finiteness conditions of the type satisfied by arithmetic groups. We define a representation ring for $\Gamma$, determined on its elements of finite order, which is of finite type. Then we determine the contribution of this ring to the topological $K$-theory $K^*(B\Gamma)$, obtaining an exact formula for the difference in terms of the cohomology of the centralizers of elements of finite order in $\Gamma$.Comment: 4 page